The release of thromboxane A2 and prostacyclin following experimental acute pulmonary embolism. Reeves WC, Demers LM, Wood MA, Skarlatos S, Copenhaver G, Whitesell L et al. New concepts of amniotic fluid embolism: a review. Amniotic fluid amnio as possible factor in etiology of eclampsia. United Kingdom amniotic fluid embolism register. Acute hemodynamic and respiratory effects of amniotic fluid embolism in the pregnant goat model. Hankikns GD, Snyder RR, Clarke SL, Schwartz L, Patterson WR, Clifford A. Amniotic fluid embolism: analysis of the national registry. Maternal pulmonary embolism by fluid as a cause of obstetric shock and unexpected deaths in obstetrics.
1979 30:20-6.Ĭlarke SL, Hankins G, Dudley DA, Dildy GA, Porter TF. Hence prompt diagnosis and effective supportive measures is the key in the management. The mortality and morbidity due to AFE is very high. The corner stone of management is a multi-disciplinary approach with support given to the failing organ systems. There are no proven risk factors though a few have been postulated. It may be due to anaphylactoid like reaction to fetal cells that enter maternal circulation.
Pathophysiology is not clearly understood. 1 It presents with shortness of breath, hypotension, hypoxemia, uterine atony, post-partum hemorrhage, disseminated intravascular coagulation, convulsions, coma and death. Department of Obstetrics and Gynecology, Sree Gokulam Medical College and Research Foundation, Venjaramoodu, Trivandrum, Kerala, Indiaĭepartment of Surgery, Medical College Allappuzha, Allappuzha, Kerala, IndiaĪmniotic fluid embolism (AFE), Disseminated intravascular coagulation (DIC), Hypoxia, Obstetric emergency AbstractĪmniotic Fluid Embolism (AFE) is an obstetric catastrophe which occurs in 1 in 8000-80000 deliveries.
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